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Drug resistance, whatever its source, is the prevalent cause for treatment failure in cancer chemotherapy. At present, the best understood (and most publicized) mechanism of cell resistance is the P-glycoprotein mediated efflux pump. However, it is not the only - or even the most effective - tool of survival devices to be considered in this book. Alterations of topoisomerases and conjugases, glutathione transferases, protein kinase C, the multidrug resistance protein MRP, bc12 and other modes of action are considered as well. By identifying and understanding how multidrug resistance in cancer evolves and functions, we should be able to prevent, circumvent or reverse this so far inescapable phenomenon. Featuring a collection of reviews by scientists, this book attempts to achieve an understanding of the molecular basis for drug resistance. It is intended for researchers in such diverse fields as chemotherapy, drug delivery, oncology, pathology, pharmacokinetics, tumour biology and biological response modifiers.

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Researching Complementary and Alternative Medicine provides a valuable and timely resource for those looking to understand, initiate and expand CAM research.

This collection brings together leading international CAM researchers with backgrounds and expertise in a variety of areas including health social science, qualitative methodology, general practice, health services research and public health. Drawing upon their own research work and experience, the contributors explain and review core methods and research issues pertinent to contemporary CAM and its future development. Topics discussed include:

• the use and limitation of evidence in CAM research
• the issues facing practitioners (GPs, therapists, nurses, etc) who wish to conduct research
• how and why qualitative methods should be combined alongside quantitative methods to help explore CAM
• how the randomised control trial (RCT) method relates to CAM
• the future direction of CAM research in terms of public health and policy-related agendas.

Researching Complementary and Alternative Medicine is essential reading for students, academics and researchers in CAM, health studies, medicine, nursing, medical sociology and public health. It will also appeal to CAM and allied health practitioners.

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As our knowledge of the passive response to fear in animals deepens, a clearer understanding of the human fear response will emerge. But there is more to science than facts and discoveries and breakthroughs. Scientific research has its own compensation. Doing the work of science is rewarding. Working outside with camera and binoculars while becoming one with nature is awe-inspiring. Discovering the secrets of how animals live and what they do and why they do it is the most satisfying thing I have ever accomplished. Animals do interesting things. Our respect for animals and all of nature increases as we try to fathom the complexities of even commonplace creatures. One of the most exciting aspects of scientific adventure is not knowing where it will lead. My curiosity about how alligators stayed warm started me on a journey of wonderment to how hiding animals respond to fear. And that journey lead to the crib of a baby at risk for an insidious killer. It is impossible to anticipate where future research into the passive fear response will lead. One fact is abundantly clear; it will be an exciting voyage into the unknown.

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