Statistical Methods in Cancer Research Vol. 1 : The Analysis of Case-Control Studies by International Agency for Resea 
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This concise guidebook consolidates the main concepts of the cancer gene theory, and provides a framework for understanding the genetic basis of cancer. Focused on the most highly representative genes that underlie the most common cancers, the book is aimed at advanced undergraduates who have completed introductory courses in genetics, biology and biochemistry, medical students, and house medical house staff preparing for board examinations. Primary attention is devoted to the origins of cancer genes and the application of evolutionary theory to explain why the cell clones that harbor cancer genes tend to expand.
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Using a unique framework, Fundamentals of Cancer Epidemiology, Second Edition, helps readers develop an in-depth understanding of the current body of knowledge on cancer what it is, how it is defined, how it develops in biological and genetic terms, which groups are at highest risk, and what causes it.
Review : Radiation from Medical Procedures in the Pathogenesis of Cancer and Ischemic Heart Disease: Dose-Response Studies with Physicians per 100,000 Population
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First the Bad News, Then the Good News. An honored scientist, who has a fine track-record of being correct, uncovers the first powerful evidence that xray procedures are a MAJOR cause, for men and women, of Cancer AND of Ischemic Heart Disease (also called Coronary Heart Disease, Coronary Artery Disease, and Myocardial Ischemia).
These two discoveries (not previously published elsewhere) point to a safe and painless way to achieve big reductions in mortality from both diseases --- because the undeniable benefits of xray procedures can be obtained, demonstrably, at much lower levels of xray dosage. Exposure to xrays, including fluoroscopy and CT scans, is a well-established cause of structural chromosomal aberrations and other mutations, even at very low doses and dose-rates.
Because the author's two discoveries are so startling, he shares at the outset (Chapter 1) the eight reasons which combine to make him confident that the findings are scientifically sound.
The content of this book is important to everyone who has either a professional or a personal interest in understanding and preventing Cancer and Ischemic Heart Disease. These two diseases account for 45% of deaths in the USA. The book presents strong evidence that medical radiation is one of their important causes.
Like detectives, many readers ENJOY evaluating evidence of causation. They seek data-and-logic, and are not intimidated by it. Such readers will find this to be a reader-friendly book. It uses no complex statistical operations. It shows each step between the raw data and the conclusions. And, because readers will "arrive" from many different fields, it defines even basic terms and concepts.
The nature of the evidence in this book will be comprehensible not only to biomedical and public health scientists, physicians, and undergraduate students worldwide, but also to non-medical scientists, engineers, lawyers, and health activists. The book begins with a short Introduction, an Abstract, and an Executive Summary.
Nearly all physicians --- whether they be radiologists, surgeons, gynecologists, cardiovascular specialists, general practitioners, or other --- either administer or "order" medical xrays. They need to know the findings and implications of this book for the health of their patients, regarding two of the most serious diseases in the United States. One implication: The undeniable benefits of xrays need to be, and demonstrably can be, obtained at much lower dose-levels than the levels commonly in use.
Patients today, who diligently inform themselves about the causes and prevention of various ailments, may wish to talk over the discoveries in this book with their own physicians.
Scientific inquiry is often organized around the exploration of hypotheses. Evidence is presented to test the validity of the hypotheses in logical ways. While an untested hypothesis is a speculation, hypotheses which PASS appropriate tests are the very substance of scientific knowledge.
This book presents a mountain of evidence which supports the two hypotheses stated on the book's cover. The first is that medical radiation is a highly important cause (probably the principal cause) of cancer mortality in the United States during the Twentieth Century. The second is that medical radiation, received even at very low and moderate doses, is an important cause of death from Ischemic Heart Disease; the probable mechanism is radiation-induction of mutations in the coronary arteries, resulting in dysfunctional clones (mini-tumors) of smooth muscle cells.
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The story of the new scientific breakthroughs that have revolutionized the treatment of cancer and other terminal illnesses. The author is a world authority on cancer and its treatment. His quest for a cure began in 1968 when a patient of his with inoperable cancer recovered spontaneously. Had the man's immune system somehow killed the tumour? And if so, can the body rid itself of cancer? From this moment on, Dr Rosenberg seized upon immunotherapy as the most promising path towards a cure for the disease. Most recently he has pioneered gene therapy, a technique in which a patient's own genes are altered in the laboratory and then reintroduced into the bloodstream to attack tumours. So far, his efforts have been profoundly encouraging. The narrative has the power and pace of a thriller - a thriller in search of the keys to life itself.
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In 1961, twenty-eight-year-old Dr. Judah Folkman saw something while doing medical research in a United
States navy lab that gave him the first glimmering of a wild, inspired hunch. What if cancerous tumors, in order to expand, needed to trigger the growth of new blood vessels to feed themselves? And if that was true, what if a way could be found to stop that growth? Could cancers be starved to death? Dr. Folkman had ample reason to be self confident — second in his class at Harvard Medical School, he was already considered one of the most promising doctors of his generation. But even he never guessed that his idea would eventually grow into a multibillion-dollar industry that is now racing through human trials with drugs that show unparalleled promise of being able to control cancer, as well as other deadly diseases.
For the creation of this book, Dr. Judah Folkman cooperated fully and exclusively with acclaimed science writer Robert Cooke. He granted Cooke unlimited interviews, showed him diaries and personal papers, and threw open the doors of his lab. The result is an astonishingly rich and candid chronicle of one of the most significant medical discoveries of our time and of the man whose vision and persistence almost single-handedly has made it possible.
Dr. Folkman's radical new way of thinking about cancer was once considered preposterous. So little was known about how cancer spreads and how blood vessels grow that he wasn't even taken seriously enough to be considered a heretic. Other doctors shook their heads at the waste of a great mind, and ambitious young medical researchers were told that accepting a position in Folkman's lab would be the death of their careers. Now, though, the overwhelming majority of experts believes that the day will soon come when antiangiogenesis therapy supplants the current more toxic and less-effective treatments — chemotherapy, radiation, and surgery-as the preferred method of treatment for cancer in patients around the world, and Dr. Folkman's breakthrough will come to be taken for granted the way we now take for granted the polio vaccine and antibiotics.
Dr. Folkman's War brilliantly describes how high the odds are against success in medical research, how vicious the competition for grants, how entrenched the skepticism about any genuinely original thinking, how polluted by politics and commerce the process of getting medicine into patients' hands. But it also depicts with rare power how exalted a calling medicine can be and how for the rare few—the brilliant, the tireless, and the lucky — the results of success can be world-changing.
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For decades now, treatment for cancer has been limited to radiation, chemotherapy, surgery, and herbal remedies—all of which offering only a small measure of hope for recovery. Now, however, there may be another option with even better results. Author Anthony J. Luksas, PhD, has dedicated over fifty years to research for not just a treatment, but a cure. His decades in the field have led him to the discovery of the ages: a road map to a cure for cancer using DNA.
Since its discovery in 1953 by Watson and Crick, the DNA double helix has been thought of as the language of God. From that point on, throughout the ensuing decades, research has decoded much of that language, giving scientists a more respectable insight into the paradox of life itself. Now, furthering that insight, Dr. Luksas has determined a means of using that language to address cancer and perhaps other diseases.
Providing a wealth of information on DNA and how it functions in the body, as well as other processes important to the replication of cancerous bodies such as cell respiration and metastasis, Dr. Luksas explains his findings with the common reader in mind.
