Best The Laboratory Mouse (Handbook of Experimental Animals)

The Laboratory Mouse (Handbook of Experimental Animals) by Academic Press




Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimer's, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.

One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model.

* Edited by Hans Hedrich, Hannover Medical School
* Comprehensive reference source written by international experts
* Well-illustrated with high quality detailed images
* Two-color, user-friendly format combined with color plate sectionsRead more The Laboratory Mouse (Handbook of Experimental Animals)

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AN INTRODUCTION TO THE STUDY OF EXPERIMENTAL MEDICINE Reviews

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This reference series will provide all researchers using laboratory animals with comprehensive practical information on the various species. Each title in the series is devoted to a particular species, and draws together all available data in a "one-stop", easily accessible source. Each has similar format, with sections on the strains available, their husbandry, and special diets. Also included are sections on gross anatomy, endocrinology, and reproduction, followed by more detailed sections on neuroanatomy, vasculature, cell biology, and histology of particular organs and structures, and a section on molecular biology.
High quality illustrations are included throughout and a color plate section is provided. A glossary, list of equipment suppliers, and "Quick Reference Section" are added features. The "Quick Reference Section" brings together all tables from the text, allowing readers to find data swiftly.
The first volume in The Handbook of Experimental Animals Series, The Laboratory Rat, provides researchers in academia and industry using laboratory animals with comprehensive, practical information on the species. The Laboratory Rat has been divided into eight sections dealing with:
* Strains and their selection for research
* Housing and maintenance
* Pathogens and diseases
* Breeding and reproduction
* Anatomy
* Physiology
* Procedures, including experimental surgery
* Emerging techniques, including genetic engineering and molecular technology

Key Features
* Provides a valuable, comprehensive reference source for anybody working with the laboratory rat
* Formatted in a two-color, user-friendly layout
* Includes high-quality illustrations throughout as well as a color plate section
* Glossary
* Tables in the text are also arranged into one Quick Reference Section for ease of access to the data
* Appendix of equipment suppliers

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Best Power Analysis for Experimental Research: A Practical Guide for the Biological, Medical and Social Sciences

Power Analysis for Experimental Research: A Practical Guide for the Biological, Medical and Social Sciences by Cambridge University Press




Power analysis is an essential tool for determining whether a statistically significant result can be expected in a scientific experiment prior to the experiment being performed. This comprehensive, accessible book provides practicing researchers with step-by-step instructions for conducting power/sample size analyses, assuming only basic prior knowledge of summary statistics and normal distribution. It contains a unified approach to statistical power analysis, with numerous easy-to-use tables that make further calculations or statistical expertise unnecessary.Read more Power Analysis for Experimental Research: A Practical Guide for the Biological, Medical and Social Sciences

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This volume focuses on considerations that maximize both scientific benefit and animal well-being for major species of animals used in biomedical research. Each species is discussed in terms of uses in research; basic biology; husbandry requirements; proper handling; disease control; anesthesia, analgesia, and stress control; natural behavior, behavioral needs, psychological needs, and social needs; and ideal environment for the animals. This book is a must for anyone working with experimental animals.

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The publication of this Second Edition, twelve years after the first, attests to the timelessness of the techniques used in experimental work with the rat. However, scientific progress inevitably brings to light new ideas and procedures. In particular, considerable progress has been made in the use of new anesthetics and analgesics. A completely new chapter has been written on these with unique emphasis on the applicability to the rat. The very variable standards of surgery that existed in the past are placed in perspective in another new chapter, which makes recommendations more in keeping with the higher standards now demanded of animal experimentation. A variety of new techniques have been added throughout to expand the usefulness of the book, and more illustrations have been added to help in the execution of the various procedures.
One of the greatest advances in the last twelve years is a greater appreciation for the well-being of experimental animals, and references to a more humane and refined approach have been made throughout this edition. This greater awareness of welfare issues demands that experimental animals be handled and used correctly and compassionately, with as little suffering as possible, and has led to a marked improvement in the attitude to proper training.
This book is still the only source which provides a detailed and up-to-date compilation of illustrated experimental methods for work with the rat. It will continue to be an invaluable reference to specific information for laboratory workers and will help considerably in training new investigators in the proper and considerate use of this species.

Key Features
* All surgical techniques have been revised and updated
* A new section on anesthesia and post-operative care has been included
* Presents new techniques, particularly cannulation

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Let this down-to-earth book be your guide to the statistical integrity of your work. Without relying on the detailed and complex mathematical explanations found in many other statistical texts, Principles of Experimental Design for the Life Sciences teaches how to design, conduct, and interpret top-notch life science studies. Learn about the planning of biomedical studies, the principles of statistical design, sample size estimation, common designs in biological experiments, sequential clinical trials, high dimensional designs and process optimization, and the correspondence between objectives, design, and analysis. Each of these important topics is presented in an understandable and non-technical manner, free of statistical jargon and formulas.
Written by a biostatistical consultant with 25 years of experience, Principles of Experimental Design for the Life Sciences is filled with real-life examples from the author's work that you can quickly and easily apply to your own. These examples illustrate the main concepts of experimental design and cover a broad range of application areas in both clinical and nonclinical research. With this one innovative, helpful book you can improve your understanding of statistics, enhance your confidence in your results, and, at long last, shake off those statistical shackles!

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This illustrated textbook for biologists provides a refreshingly clear and authoritative introduction to the key ideas of sampling, experimental design, and statistical analysis. The author presents statistical concepts through common sense, non-mathematical explanations and diagrams. These are followed by the relevant formulae and illustrated by worked examples. The examples are drawn from all areas of biology, from biochemistry to ecology and from cell to animal biology. The book provides everything required in an introductory statistics course for biology undergraduates, and it is also useful for more specialized undergraduate courses in ecology, botany, and zoology.

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Power analysis is an essential tool for determining whether a statistically significant result can be expected in a scientific experiment prior to the experiment being performed. This comprehensive, accessible book provides practicing researchers with step-by-step instructions for conducting power/sample size analyses, assuming only basic prior knowledge of summary statistics and normal distribution. It contains a unified approach to statistical power analysis, with numerous easy-to-use tables that make further calculations or statistical expertise unnecessary.

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Clear and penetrating presentation of the basic principles of scientific research from the great French physiologist whose contributions in the 19th century included the discovery of vasomotor nerves; nature of curare and other poisons in human body; functions of pancreatic juice in digestion; elucidation of glycogenic function of the liver.

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Bernard was born in 1813 in the village of Saint-Julien near Villefranche-sur-Saône. He received his early education in the Jesuit school of that town, and then proceeded to the college at Lyon, which, however, he soon left to become assistant in a druggist's shop. His leisure hours were devoted to the composition of a vaudeville comedy, and the success it achieved moved him to attempt a prose drama in five acts, Arthur de Bretagne.
In his major discourse on scientific method, An Introduction to the Study of Experimental Medicine (1865), Claude Bernard describes what makes a scientific theory good and what makes a scientist important, a true discoverer. Unlike many scientific writers of his time, Bernard writes about his own experiments and thoughts, and uses the first person.[3]
Known and Unknown. What makes a scientist important, he states, is how well he or she has penetrated into the unknown. In areas of science where the facts are known to everyone, all scientists are more or less equal-we cannot know who is great. But in the area of science that is still obscure and unknown the great are recognized: "They are marked by ideas which light up phenomena hitherto obscure and carry science forward".[4]
Authority vs. Observation. It is through the experimental method that science is carried forward--not through uncritically accepting the authority of academic or scholastic sources. In the experimental method, observable reality is our only authority. Bernard writes with scientific fervor:
"When we meet a fact which contradicts a prevailing theory, we must accept the fact and abandon the theory, even when the theory is supported by great names and generally accepted"[5]
Induction and Deduction. Experimental science is a constant interchange between theory and fact, induction and deduction. Induction, reasoning from the particular to the general

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To diminish the learning curve associated with using swine as models, Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition provides practical technical information for the use of swine in biomedical research. The book focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest.

New to the Second Edition

Updated sections on anesthesia and perioperative care, including practical information for more complex models

Expansion of anatomic and physiologic details

Additional detail in the endoscopy section

Chapters on toxicology and radiobiology

Chapters that include angiographic, echocardiographic, CT, MRI, and PET imaging techniques with a corresponding DVD of the images

More tables of normal values on the most commonly used minipigs and domestic breeds

Beneficial for investigators, veterinarians, and technicians using swine for experimental and agricultural procedures, Swine in the Laboratory is certain to foster the appropriate, humane use of swine in biomedical research.

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