Showing posts with label life. Show all posts
Showing posts with label life. Show all posts

Saturday, June 22, 2013

Best At the Close of Day a Person Centered Guide Book on End of Life Care



At the Close of Day a Person Centered Guide Book on End of Life Care by Streamline Pr




This book was written by a physician and an ethicist/pastor. It is designed to help the lay person understand and work through the dying process. By helping the reader to create a well designed end-of-life plan, the book serves as a valuable resource and has already helped many people to reduce fear, pain, and chaos often present during the dying process. It is also well-suited for healthy people who are thinking ahead about end-of-life documentation and planning.Read more At the Close of Day a Person Centered Guide Book on End of Life Care

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Wednesday, June 12, 2013

%$$$ Revews Principles of Experimental Design for the Life Sciences


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Main Features : Principles of Experimental Design for the Life Sciences

Let this down-to-earth book be your guide to the statistical integrity of your work. Without relying on the detailed and complex mathematical explanations found in many other statistical texts, Principles of Experimental Design for the Life Sciences teaches how to design, conduct, and interpret top-notch life science studies. Learn about the planning of biomedical studies, the principles of statistical design, sample size estimation, common designs in biological experiments, sequential clinical trials, high dimensional designs and process optimization, and the correspondence between objectives, design, and analysis. Each of these important topics is presented in an understandable and non-technical manner, free of statistical jargon and formulas.
Written by a biostatistical consultant with 25 years of experience, Principles of Experimental Design for the Life Sciences is filled with real-life examples from the author's work that you can quickly and easily apply to your own. These examples illustrate the main concepts of experimental design and cover a broad range of application areas in both clinical and nonclinical research. With this one innovative, helpful book you can improve your understanding of statistics, enhance your confidence in your results, and, at long last, shake off those statistical shackles!






Sunday, June 9, 2013

Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes Shopping


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Product Name : Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes

Quality of life studies form an essential part of the evaluation of any treatment. Written by two authors who are well respected within this field, Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes, Second Edition lays down guidelines on assessing, analysing and interpreting quality of life data. The new edition of this standard book has been completely revised, updated and expanded to reflect many methodological developments emerged since the publication of the first edition.

  • Covers the design of instruments, the practical aspects of implementing assessment, the analyses of the data, and the interpretation of the results
  • Presents all essential information on Quality of Life Research in one comprehensive volume
  • Explains the use of qualitative and quantitative methods, including the application of basic statistical methods
  • Includes copious practical examples
  • Fills a need in a rapidly growing area of interest
  • New edition accommodates significant methodological developments, and includes chapters on computer adaptive testing and item banking, choosing an instrument, systematic reviews and meta analysis

This book is of interest for everyone involved in quality of life research, and it is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and practitioners in the fields of cancer and other chronic diseases.

Reviews of the First Edition – Winner of the first prize in the Basis of Medicine Category of the BMA Medical Book Competition 2001:

“This book is highly recommended to clinicians who are actively involved in the planning, analysis and publication of QoL research." CLINICAL ONCOLOGY

“This book is highly recommended reading."  QUALITY OF LIFE RESEARCH

Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes

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Saturday, June 8, 2013

Best Say NO to Aging: How Nitric Oxide (NO) Prolongs Life



Say NO to Aging: How Nitric Oxide (NO) Prolongs Life by Norlightspress.Com




In Say NO to Aging, physicians T. Barry and Arlene B. Levine answer the urgent question: How can we slow and reverse aging’s relentless advance? Using stories and examples, the authors guide us through our bodies at the cellular level, showing how lifestyle choices affect the biochemistry of disease and aging. Mitochondria, telomeres, longevity genes, adult stem cells, and cell protection mechanisms keep us healthy for many decades, but they are not infinitely renewable. Say NO to Aging explains how the diseases of aging set in. Say NO to Aging introduces readers to nitric oxide (NO)—a tiny, but immensely important molecule that replenishes our non-renewable life resources and rejuvenates the blood vessels, heart, metabolism, and brain. We can delay aging with easy, yet powerful, lifestyle changes. Drs. Levine provide detailed recommendations on food choices, diets, exercise, and stress reduction practices. They explain how these changes slow the aging process—and protect us against many chronic and lethal diseases, including heart disease, diabetes, and cancer. The authors show how modern science has incorporated ancient wisdom that first posited an active life lived in harmony and moderation is the healthiest possible choice that says NO to aging.Read more Say NO to Aging: How Nitric Oxide (NO) Prolongs Life

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Friday, June 7, 2013

Best Quality of Life: Assessment, Analysis, and Interpretation



Quality of Life: Assessment, Analysis, and Interpretation by Wiley




'Winner of first prize in the Basis of Medicine Category of the BMA Medical Book Competition 2001'

The One Essential Comprehensive Volume on Quality of Life Research. Quality of life studies are now an essential part of the evaluation of any treatment. Written by two authors who are well respected within this field, this book is the first volume to lay down guidelines on assessing, analysing and interpreting quality of life data.

Quality of Life: Assessment, Analysis and Interpretation

  • Covers development of questionnaires through to analysis of studies
  • Includes practical examples
  • Fills a need in a rapidly growing area of interest
  • Has a clear structure and consistent approach to the material covered
This book is aimed at everyone involved in quality of life and is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and practitioners in the fields of cancer and other chronic diseases. Read more Quality of Life: Assessment, Analysis, and Interpretation

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Thursday, June 6, 2013

****** Best Revews Quality of Life in Health Promotion and Rehabilitation: Conceptual Approaches, Issues, and Applications


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Quality of Life in Health Promotion and Rehabilitation: Conceptual Approaches, Issues, and Applications Description

This book convincingly argues that Quality of Life is the vital link between health promotion and rehabilitation. The contributors first review the conceptual basis for understanding and discussing quality of life in health promotion and education. They continue by addressing critical issues such as ethics, policy, quality assurance, and measurement - exploring applications of quality of life in the context of a wide range of current social issues and populations. Finally, they consider the implications for future research and practice.






+++ Best Revews Aging by Design: How New Thinking on Aging Will Change Your Life


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Why do we age? How do we age? These questions have baffled scientists for centuries and remain unresolved. The answer to the “how" question is critical to our ability to successfully prevent and treat age-related diseases like cancer and heart disease that now cause the majority of all deaths in the developed world. Because of major difficulties in directly experimentally determining causes of aging, the answer to the “why" question is critical to guiding research efforts directed toward identifying and altering processes involved in age-related diseases.
Evolution theory plays a critical role in the “why" issue because it attempts to explain why each living organism has its particular design and therefore why different species display different aging characteristics and different life spans.
This short book describes the history and current status of attempts to explain why we age extending from Darwin’s 1859 theory to the present day. The author provides colorful and interesting descriptions of the theorists, their theories, the discoveries and the controversies that have led us to the current situation: Although there is very wide scientific agreement about most aspects of evolution theory, four different theories now exist concerning the fine details that apply to aging. These four theories lead to radically different concepts regarding the actual biological mechanisms behind the aging process and consequently the mechanisms behind age-related diseases.
The book goes on to discuss observations and experiments that offer clues as to the nature of biological aging mechanisms. These include apparently non-aging animals, worm experiments, rat blood-exchange experiments, caloric restriction experiments, octopus experiments, and the discovery of genes that cause aging.
Goldsmith then leads us through an analysis that concludes, based on the direct evidence and current status of the evolution theories, that programmed aging is the aging theory that best matches all of the evidence. We age because we are designed to age. We are designed to age because a limited life span conveys an evolutionary benefit. Most current medical researchers believe in non-programmed aging and much of the evidence for programmed aging comes from non-human sources. If the programmed theory of biological aging, first proposed in 1882, is indeed correct, it has major implications regarding the way we think about and seek to prevent or treat age-related diseases. It also suggests that it may well be possible in the relatively near term to generally delay the aging process. Which theory is correct could therefore greatly affect many people now alive! The book describes some current programmed aging researchers, research activities, and results.
A final question is discussed: How could we be living in the twenty-first century and still not have scientific agreement on even the fundamental nature of aging? The author suggests that several “non-science factors" including the sequence in which various theories were developed and the perception that the issue was “academic" have influenced thinking and delayed the development of scientific agreement.
ISBN: 978-0-9788709-3-5
Revised edition 7/2012

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Wednesday, June 5, 2013

%$$$ Best Revews The Randomness of Life


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Barranquitas, Venezuela is real. Nearly half of its population has inherited a malicious, mutated gene that causes a deadly neurological disease. Marina Valdesa, age 36, lies dying in a Casa Hogar Amor y Fe, or House of Love and Hope. Her nine children will be orphaned and may inherit the same fate as their mother. Daniel, a 39-year-old nursing home resident outside Chicago shares Marina's deadly diagnosis as researchers in academia and industry attempt relentlessly to discover a cure. Their mutual plight is one of mystery, devastation, hope and soul searching. The quality of their lives gets microscoped just like their diminishing brain cells. Marina's 18-year-old daughter Tula, escapes her homeland and accompanies an American volunteer to Chicago to participate in a clinical trial at a leading University Hospital. As Tula is introduced to the latest pharmaceutical attempts and research studies to eradicate the loss of our minds and bodily functions we learn through other characters that salvation arrives from unconditional love. In a world that advocates the benefits of Omega III, fish oil, salmon and blueberries, we cannot put off death. We learn to experience healing without a cure and relief in the face of suffering. The Randomness of Life is a compassionate portrayal of some of life's real heroes and their families. Author Bio: Marilyn Warda, a Northwest Indiana native is a medical practice manager now working in Southwest Arizona. She has experienced the trials for caring for those suffering from debilitating neurological disease. Marilyn has a BA degree from Purdue University where she majored in communications and journalism. In her debut novel, The Randomness of Life, she allows the reader to see themselves in every chapter and face the ultimate of one's fears. keywords: Quality of Life, Hope, Alzheimer's, Gene Silencing, Heroes, Clinical Trials, Human Genome Project, Huntington's Disease, Nursing Homes, Medical Research, Pharmaceutical Advances, Death, Soul Searching

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Tuesday, May 28, 2013

%$$$ Best Revews How to Win the Nobel Prize: An Unexpected Life in Science (Jerusalem-Harvard Lectures)


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Main Features : How to Win the Nobel Prize: An Unexpected Life in Science (Jerusalem-Harvard Lectures)

In 1989 Michael Bishop and Harold Varmus were awarded the Nobel Prize for their discovery that normal genes under certain conditions can cause cancer. In this book, Bishop tells us how he and Varmus made their momentous discovery. More than a lively account of the making of a brilliant scientist, How to Win the Nobel Prize is also a broader narrative combining two major and intertwined strands of medical history: the long and ongoing struggles to control infectious diseases and to find and attack the causes of cancer.

Alongside his own story, that of a youthful humanist evolving into an ambivalent medical student, an accidental microbiologist, and finally a world-class researcher, Bishop gives us a fast-paced and engrossing tale of the microbe hunters. It is a narrative enlivened by vivid anecdotes about our deadliest microbial enemies--the Black Death, cholera, syphilis, tuberculosis, malaria, smallpox, HIV--and by biographical sketches of the scientists who led the fight against these scourges.

Bishop then provides an introduction for nonscientists to the molecular underpinnings of cancer and concludes with an analysis of many of today's most important science-related controversies--ranging from stem cell research to the attack on evolution to scientific misconduct. How to Win the Nobel Prize affords us the pleasure of hearing about science from a brilliant practitioner who is a humanist at heart. Bishop's perspective will be valued by anyone interested in biomedical research and in the past, present, and future of the battle against cancer.






Sunday, May 12, 2013

%$$$ Quality Design and Analysis of Quality of Life Studies in Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics)


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Design and Analysis of Quality of Life Studies in Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics)

Main Features : Design and Analysis of Quality of Life Studies in Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics)

More and more frequently, clinical trials include the evaluation of Health-Related Quality of Life (HRQoL), yet many investigators remain unaware of the unique measurement and analysis issues associated with the assessment of HRQoL. At the end of a study, clinicians and statisticians often face challenging and sometimes insurmountable analytic problems.

Design and Analysis of Quality of Life Studies in Clinical Trials details these issues and presents a range of solutions. Written from the author's extensive experience in the field, it focuses on the very specific features of QoL data: its longitudinal nature, multidimensionality, and the problem of missing data. The author uses three real clinical trials throughout her discussions to illustrate practical implementation of the strategies and analytic methods presented.

As Quality of Life becomes an increasingly important aspect of clinical trials, it becomes essential for clinicians, statisticians, and designers of these studies to understand and meet the challenges this kind of data present. In this book, SAS and S-PLUS programs, checklists, numerous figures, and a clear, concise presentation combine to provide readers with the tools and skills they need to successfully design, conduct, analyze, and report their own studies.






Saturday, May 11, 2013

*** The Immortal Life of Henrietta Lacks buy


The Immortal Life of Henrietta Lacks

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Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal" human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.

Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.

Now Rebecca Skloot takes us on an extraordinary journey, from the “colored" ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia—a land of wooden slave quarters, faith healings, and voodoo—to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.

Henrietta’s family did not learn of her “immortality" until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.

Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance? 
          
Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.






Tuesday, May 7, 2013

+++ The Chicago Guide to Your Career in Science: A Toolkit for Students and Postdocs (Chicago Guides to Academic Life) reviews


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Embarking upon research as a graduate student or postdoc can be exciting and enriching—the start of a rewarding career. But the world of scientific research is also a competitive one, with grants and good jobs increasingly hard to find. The Chicago Guide to Your Career in Science is intended to help scientists not just cope but excel at this critical phase in their careers.

Victor A. Bloomfield and Esam E. El-Fakahany, both well-known scientists with extensive experience as teachers, mentors, and administrators, have combined their knowledge to create a guidebook that addresses all of the challenges that today’s scientists-in-training face. They begin by considering the early stages of a career in science: deciding whether or not to pursue a PhD, choosing advisors and mentors, and learning how to teach effectively. Bloomfield and El-Fakahany then explore the skills essential to conducting and presenting research. The Chicago Guide to Your Career in Science offers detailed advice on how to pursue research ethically, manage time, and communicate effectively, especially at academic conferences and with students and peers. Bloomfield and El-Fakahany write in accessible, straightforward language and include a synopsis of key points at the end of each chapter, so that readers can dip into relevant sections with ease.

From students prepping for the GRE to postdocs developing professional contacts to faculty advisors and managers of corporate labs, scientists at every level will find The Chicago Guide to Your Career in Science an unparalleled resource.
 
The Chicago Guide to Your Career in Science is a roadmap to the beginning stages of a scientific career. I will encourage my own students to purchase it."—Dov F. Sax, assistant professor of ecology and evolutionary biology, Brown University
 
“Step-by-step, Victor Bloomfield and Esam El-Fakahany provide sound, thorough, yet succinct advice on every issue a scientist in training is likely to encounter. Young readers will welcome the authors’ advice on choosing a graduate school, for example, while senior scientists will probably wish that a book like this had been around when they were starting out. With down-to-earth and occasionally humorous advice, The Chicago Guide to your Career in Academic Biology belongs on the bookshelf of every graduate student and advisor."—Norma Allewell, Dean, College of Chemical and Life Sciences, University of Maryland
 







Saturday, May 4, 2013

+++ Save Quality of Life & Pharmacoeconomics: An Introduction


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Quality of Life & Pharmacoeconomics: An Introduction will familiarize students, clinicians, and researchers with the key principles and methods of quality-of-life and cost-effectiveness assessment in clinical trials. The book is based on abstracted material from the Second Edition of Dr. Spilker's definitive reference, Quality of Life and Pharmacoeconomics in Clinical Trials (1996). The material has been edited, condensed, and streamlined to provide a broad overview of approaches to quality-of-life assessment, evaluations of outcomes, and pharmacoeconomic methods. The integration of these three areas is one of the most valuable features of this introduction. Quality of Life & Pharmacoeconomics: An Introduction is divided into seven sections: introduction; social and psychological assessment; selected tests for quality-of-life assessment; reported methodology; special populations and specific diseases; utilities and outcomes; and pharmacoeconomics. Each section summarizes the crucial issues and provides selected references

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Thursday, May 2, 2013

%$$$ Save Quality of Life and Pharmacoeconomics in Clinical Trials


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The Second Edition of this groundbreaking work refines the art and science of quality of life assessment and pharmacoeconomics and redefines the role of these evaluation parameters in clinical trials and health care decision-making. Dr. Spilker has assembled more than 200 experts from diverse clinical, research, and social science disciplines to provide a comprehensive reference on the methodology, interpretation, and use of quality of life and pharmacoeconomic studies. Expanded to four times its predecessor's size and scope, the Second Edition features: all-new sections on pharmacoeconomics and crucial health policy issues such as outcomes research a new, extensive section on cross-cultural and cross-national issues in quality of life assessment detailed information on specific tests and measures of quality of life comprehensive guidelines on choosing and administering tests and analyzing, interpreting, and presenting data many chapters on new topics such as phenomenology, assessment of spiritual status, and alternative/complementary medical treatments

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Tuesday, April 30, 2013

Assessing Quality of Life in Clinical Trials: Methods and Practice Shopping


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Assessing Quality of Life in Clinical Trials: Methods and Practice


Researchers in all clinical fields are fully aware of the importance of Quality of Life measurements in judging the efficacy of a given treatment. Psychological criteria play an important role in this evaluation. Assessment of Quality of Life in Clinical Trials: methods and practice explores the current state of the art and illustrates the benefits and potential of health related quality of life assessment in clinical trials. It covers a wide range of analytical issues, emphasizing new and innovative approaches that are of practical and clinical importance.

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Saturday, April 27, 2013

The Language of Life: How Cells Communicate in Health and Disease Shopping


Review The Language of Life: How Cells Communicate in Health and Disease

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The Language of Life: How Cells Communicate in Health and Disease


Cooperation requires conversation. Human beings speak to one another. Sounds, scents, and postures allow animals to make their point. While individual cells can’t talk, hiss, growl, or bare their teeth, they nevertheless communicate regularly. Their language is based not on words or gestures, but on chemistry —using molecules where we would use words, constructing sentences from chains of proteins. The cells that make up the bodies of muticellular organisms inform, wheedle, command, exhort, reassure, nurture, criticize, and instruct each other to direct every physiological function, report every newsworthy event, record every memory, heal every wound. And each of those chemical conversations represents an opportunity for scientists and physicians.

The molecular biologists who worked for over a decade to sequence the human genome have sometimes referred to that sequence as the “book of life." To our cells, that “book" is no more than a dictionary—only living cells can converse, forming the network that allows our 60 trillion cells to function as a single organism.

For nearly a century, researchers have been straining to hear the whispered conversations among cells, hoping to master the basics of their language. They know that if we can decipher and translate this cellular chatter, we have the potential for sending signals of our own that could repair wounds, reduce cholesterol, control insulin levels, or even block the reproduction of cancer cells. The possibilities are as endless as they are intriguing. The Language of Life is a fantastic story of discovery, blending the vision of science with the poetry of life itself.

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