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The first set of case studies on animal use, this volume offers a thorough, up-to-date exploration of the moral issues related to animal welfare. Its main purpose is to examine how far it is ethically justifiable to harm animals in order to benefit mankind. An excellent introduction provides a framework for the cases and sets the background of philosophical and moral concepts underlying the subject.
Sixteen original, previously unpublished essays cover controversies associated with the human use of animals in a broad range of contexts, including biomedical, behavioral, and wildlife research, cosmetic safety testing, education, the food industry, commerce, and animal use as pets and in religious practices. Scientific research is accorded the closest scrutiny. The authors represent a wide range of expertise within their specialized areas of research--physiology, public policy, ethics, philosophy, law, veterinary science, and psychology. The careful analysis of each case makes it possible to elevate the discourse beyond over-simplified positions, and to demonstrate the complexity of the issues. The Human Use of Animals will be welcomed by students and faculty in law, philosophy, ethics, public policy, religion, medicine, and veterinary medicine. It will also interest activists in the animal protection movement, and members of animal protection organizations and Institutional Animal Care and Use Committees.

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Best Statistical Methods in Cancer Research Vol. 1 : The Analysis of Case-Control Studies

Statistical Methods in Cancer Research Vol. 1 : The Analysis of Case-Control Studies by International Agency for Resea




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LSD: Still With Us After All These Years: Based on the National Institute of Drug Abuse Studies on the Resurgence of Contemporary LSD Use Shopping

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The facts about LSD

A new book on LSD is long overdue, but this was worth waiting for. The material is thoughtful and carefully prepared, and the collection brings the topic into the 1990s. The book should be in every library, and read by everyone interested in the American drug scene.
--James A. Inciardi, Ph.D., professor and director, Center for Drug and Alcohol Studies, University of Delaware

The authors offer an insightful look at LSD use and provide an essential resource for parents, counselors, and educators. Far from fading out after the 1960's LSD has in fact never gone away, and the percentage of high school seniors using the drug is now only slightly lower than it was twenty years ago. The book examines why young people in the 1990s are using LSD--its appeal, its experience, and where kids are getting it. Solidly researched and dispassionately written, this book weaves current studies and anecdotes with recent statistics to create a vivid, complete, and credible picture of contemporary LSD use.

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This book presents a logical system of critical appraisal, to allow readers to evaluate studies and to carry out their own studies more effectively. This system emphasizes the central importance of cause and effect relationships. Its great strength is that it is applicable to a wide range of issues, and both to intervention trials and observational studies.

This system unifies the often different approaches used in epidemiology, health services research, clinical trials, and evidence-based medicine, starting from a logical consideration of cause and effect. The author's approach to the issues of study design, selection of subjects, bias, confounding, and the place of statistical methods has been praised for its clarity and interest. Systematic reviews, meta-analysis, and the applications of this logic to evidence-based medicine, knowledge-based health care, and health practice and policy are discussed. Current and often controversial examples are used, including screening for prostate cancer, publication bias in psychiatry, public health issues in developing countries, and conflicts between observational studies and randomized trials. Statistical issues are explained clearly without complex mathematics, and the most useful methods are summarized in the appendix.

The final chapters give six applications of the critical appraisal of major studies; randomized trials of medical treatment and prevention, a prospective and a retrospective cohort study, a small matched case-control study, and a large case-control study. In these chapters, sections of the original papers are reproduced and the original studies places in context by a summary of current developments.

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Buy Literary Research Guide: An Annotated Listing of Reference Sources in English Literary Studies

Literary Research Guide: An Annotated Listing of Reference Sources in English Literary Studies by Modern Language Association of America




James L. Harner's Literary Research Guide, which Choice calls "the standard guide in the field," evaluates important reference materials in English studies. Since the publication of the first edition in 1989, tens of thousands of students and educators have used the Guide as an aid to scholarly research. Harner has added entries describing resources published since 1997 and has revised nearly half the entries from the third edition. The fourth edition contains more than 1,200 entries, which discuss an additional 1,494 books, articles, and electronic resources and cite 729 reviews. New entries reflect the expansion of literary study into emerging fields (gay, lesbian, and transgendered studies and postcolonial theory); this edition also lists reliable Web sites sponsored by academic institutions and learned societies. The annotations describe the type of work, its scope, its major limitations, and its organization present parts of a typical entry in the work list the type and number of indexes evaluate coverage, organization, and accuracy explain the work's uses in research cite significant reviews that more fully define the importance or uses of the work or its place in the scholarly tradition note related works, including supplementary, complementary, or superseded ones not accorded separate entries in the Guide The Guide concludes with name, title, and subject indexes.Read more Literary Research Guide: An Annotated Listing of Reference Sources in English Literary Studies

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%$$$ Save Design and Analysis of Bioavailability and Bioequivalence Studies (Statistics: a Series of Textbooks and Monogrphs)

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This practical reference/text, written at a basic mathematical and statistical level, presents important statistical concepts for assessing bioequivalence through "real" examples and provides a thorough, unified discussion of the design and analysis of bioavailability and bioequivalence studies. Furnishing a comprehensive overview of the field and comparing average bioavailability methods, "Design and Analysis of Bioavailability and Bioequivalence Studies": supplies a simple formula for sample size determination; explains techniques for checking model assumptions and detecting outlying data; compares the additive model and the multiplicative model; demonstrates statistical methods of assessing more than two formulations; and delineates bioequivalence assessment with negligible plasma levels. As a fundamental text in the classroom or for self-education, "Design and Analysis of Bioavailability and Bioequivalence Studies": contains various study designs based on different needs and objectives; offers over 400 display equations but requires no mathematics beyond simple algebra; and incorporates time-saving SAS programmes and an appendix of statistical tables. "Design and Analysis of Bioavailability and Bioequivalence Studies" is intended for biostatisticians; applied statisticians; biometricians; pharmacologists; clinical, industrial and research pharmacists; and drug regulatory personnel; as well as an for all upper-level undergraduate and graduate courses in bioavailability and bioequivalence, pharmacokinetics, pharmaceutics and biostatistics.

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This book provides research workers with the statistical background needed in order to collect and analyze data in an intelligent and critical manner. Key examples and case studies are used to illustrate commonly encountered research problems and to explain how they may be solved or even avoided altogether. Professor Manly also presents a clear understanding of the opportunities and limitations of different research designs, as well as an introduction to some new methods of analysis that are proving increasingly popular. Topics covered include: the differences between observational and experimental studies, the design of sample surveys, multiple regression, interrupted time series, computer intensive statistics, and the ethical considerations of research. In the final chapter, there is a discussion of how the various components of a research study come together.

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Best The Progress of Experiment: Science and Therapeutic Reform in the United States, 1900-1990 (Cambridge Studies in the History of Medicine)

The Progress of Experiment: Science and Therapeutic Reform in the United States, 1900-1990 (Cambridge Studies in the History of Medicine) by Cambridge University Press




This book explores the origins of our contemporary system of drug regulation and the modern clinical trial. Marks illustrates the symbiotic relationship between the history of modern drug regulation and the history of therapeutic reform. Accompanying this history of public policy is a detailed account of changing experimental ideals and practices. Marks traces the history of therapeutic experimentation, from the "collective investigations" of the past century to the controlled clinical trial that emerged after 1950 as the paradigm of scientific experimentation. The result is the first general history of clinical research in the United States, a book that examines therapeutic experiments in a wide range of diseases, from syphilis and pneumonia to heart disease and diabetes.Read more The Progress of Experiment: Science and Therapeutic Reform in the United States, 1900-1990 (Cambridge Studies in the History of Medicine)

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Literature and the Internet: A Guide for Students, Teachers, and Scholars is the only Internet guide written for those who love and study literature. The book begins with a practical introduction for readers who want help finding, navigating, and using literary sites. Later chapters focus on educational issues such as plagiarism, citation, website evaluation, the use of Internet sites in literature courses, as well as the technical, scholarly and professional issues raised by the advent of the Internet. Finally, the book concludes with a chapter on the cultural implications of the Internet for literary studies. In addition, the book offers an annotated bibliography of Internet sources (with URLs) that introduces readers to hundreds of sites which they can explore on their own. No special training in computer technology or software is required.

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More and more frequently, clinical trials include the evaluation of Health-Related Quality of Life (HRQoL), yet many investigators remain unaware of the unique measurement and analysis issues associated with the assessment of HRQoL. At the end of a study, clinicians and statisticians often face challenging and sometimes insurmountable analytic problems.

Design and Analysis of Quality of Life Studies in Clinical Trials details these issues and presents a range of solutions. Written from the author's extensive experience in the field, it focuses on the very specific features of QoL data: its longitudinal nature, multidimensionality, and the problem of missing data. The author uses three real clinical trials throughout her discussions to illustrate practical implementation of the strategies and analytic methods presented.

As Quality of Life becomes an increasingly important aspect of clinical trials, it becomes essential for clinicians, statisticians, and designers of these studies to understand and meet the challenges this kind of data present. In this book, SAS and S-PLUS programs, checklists, numerous figures, and a clear, concise presentation combine to provide readers with the tools and skills they need to successfully design, conduct, analyze, and report their own studies.

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First the Bad News, Then the Good News. An honored scientist, who has a fine track-record of being correct, uncovers the first powerful evidence that xray procedures are a MAJOR cause, for men and women, of Cancer AND of Ischemic Heart Disease (also called Coronary Heart Disease, Coronary Artery Disease, and Myocardial Ischemia).

These two discoveries (not previously published elsewhere) point to a safe and painless way to achieve big reductions in mortality from both diseases --- because the undeniable benefits of xray procedures can be obtained, demonstrably, at much lower levels of xray dosage. Exposure to xrays, including fluoroscopy and CT scans, is a well-established cause of structural chromosomal aberrations and other mutations, even at very low doses and dose-rates.

Because the author's two discoveries are so startling, he shares at the outset (Chapter 1) the eight reasons which combine to make him confident that the findings are scientifically sound.

The content of this book is important to everyone who has either a professional or a personal interest in understanding and preventing Cancer and Ischemic Heart Disease. These two diseases account for 45% of deaths in the USA. The book presents strong evidence that medical radiation is one of their important causes.

Like detectives, many readers ENJOY evaluating evidence of causation. They seek data-and-logic, and are not intimidated by it. Such readers will find this to be a reader-friendly book. It uses no complex statistical operations. It shows each step between the raw data and the conclusions. And, because readers will "arrive" from many different fields, it defines even basic terms and concepts.

The nature of the evidence in this book will be comprehensible not only to biomedical and public health scientists, physicians, and undergraduate students worldwide, but also to non-medical scientists, engineers, lawyers, and health activists. The book begins with a short Introduction, an Abstract, and an Executive Summary.

Nearly all physicians --- whether they be radiologists, surgeons, gynecologists, cardiovascular specialists, general practitioners, or other --- either administer or "order" medical xrays. They need to know the findings and implications of this book for the health of their patients, regarding two of the most serious diseases in the United States. One implication: The undeniable benefits of xrays need to be, and demonstrably can be, obtained at much lower dose-levels than the levels commonly in use.

Patients today, who diligently inform themselves about the causes and prevention of various ailments, may wish to talk over the discoveries in this book with their own physicians.

Scientific inquiry is often organized around the exploration of hypotheses. Evidence is presented to test the validity of the hypotheses in logical ways. While an untested hypothesis is a speculation, hypotheses which PASS appropriate tests are the very substance of scientific knowledge.

This book presents a mountain of evidence which supports the two hypotheses stated on the book's cover. The first is that medical radiation is a highly important cause (probably the principal cause) of cancer mortality in the United States during the Twentieth Century. The second is that medical radiation, received even at very low and moderate doses, is an important cause of death from Ischemic Heart Disease; the probable mechanism is radiation-induction of mutations in the coronary arteries, resulting in dysfunctional clones (mini-tumors) of smooth muscle cells.

Case Studies in Forensic Epidemiology

Case Studies in Forensic Epidemiology by Springer

The discipline of epidemiology provides a methodology for perceiving the world and relating to the communities whose health and disease patterns need to be understood. Forensic epidemiology extends our understanding to community's injuries and those alleged to be responsible. This much needed resource focuses on the use of the epidemiology in the legal context, using case studies to illustrate the issues raised. This work includes discussion of:

- epidemiology in the courtroom;
- epidemiology, legislation and rulemaking;
- law, epidemiology and community organization and advocacy;
- epidemiology, law and social context.

This text challenges the boundaries about what epidemiology is and how it is to be used to make a contribution to the groups it studies. In turn, a more complete understanding of the populations, diseases and the systems that underlie and shape the research is reached. This book will be of value to the student studying in public health, environmental health and medical programs, law students as well as professional researchers.

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This is the first international and inter-disciplinary social science Handbook on health and medicine. Five years in the making, and building on the insights and advice of an international editorial board, the book brings together world-class figures to provide an indispensable, comprehensive resource book on social science, health and medicine.

Pinpointing the focal issues of research and debate in one volume, the material is organized into three sections: social and cultural frameworks of analysis; the experience of health and illness; and health care systems and practices. Each section consists of specially commissioned chapters designed to examine the vital conceptual and methodological practice and policy issues. Readers recei

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Experimentation on animals and particularly humans is often assumed to be a uniquely modern phenomenon. But the ideas and attitudes that encourage the biological and medical sciences to experiment on living creatures date from the earliest expression of Western thought. In Animal and Human Experimentation, Anita Guerrini looks at the history of these practices from vivisection in ancient Alexandria to present-day battles over animal rights and medical research employing human subjects.

Guerrini discusses in-depth key historical episodes in the use of living beings in science and medicine, including the discovery of blood circulation, the development of smallpox and polio vaccines, and recent AIDS research. She also explores the rise of the antivivisection movement in Victorian England, the modern animal rights movement, and current debates over gene therapy. In this highly accessible text, we learn how our understanding of an animal's capacity to feel pain has evolved. Guerrini reminds us that the ethical values of science seldom stray far from those of the society in which scientists live and work.

Ethical questions about the use of animals and humans in research remain among the most vexing within both the scientific community and society at large. These often rancorous arguments have gone on, however, with little awareness of their historical antecedents. Animal and Human Experimentation offers students and concerned general readers on every side of this debate a context within which to understand more fully the responsibility we all bear for the suffering inflicted on other living beings in the name of scientific knowledge.

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Case Studies in Biomedical Research Ethics (Basic Bioethics) Description

This textbook for instruction in biomedical research ethics can also serve as a valuable reference for professionals in the field of bioethics. The 149 cases included in the book are grouped in nine chapters, each of which covers a key area of debate in the field. Some of the case studies are classics, including the famous cases of the Tuskegee Syphilis Study (in which subjects with syphilis were not given treatment) and the Willowbrook hepatitis studies (in which institutionalized subjects were intentionally exposed to hepatitis). Others focus on such current issues as human embryonic stem cell research, cloning by somatic nuclear transfer, and the design and function of institutional review boards. Each chapter begins with a brief introduction that places the issues raised in context; this is followed by a number of cases (each of which is no more than a few pages). Study questions meant to encourage further discussion follow each case.After an introductory discussion of the history and tenets of ethics in medical research, the book's chapters cover the topics of oversight and study design; informed consent; the selection of subjects; conflicts of interest; the social effects of research; embryos, fetuses, and children; genetic research; the use of animals; and authorship and publication. Following these chapters are appendixes with the texts of the Nuremburg Code and the World Declaration of Geneva, two key documents in the establishment of bioethical standards for research. Also included are a glossary, a table of cases by general category, and an alphabetical listing of cases.