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provides a state-of-the-art review of medical mycology compiled by the leading researchers in the field; presents a selection of chapters covering immunological aspects of infection; captures the excitement of recently completed genome projects and their impact on the understanding of fungal biology and virulence; examines the recent advances in the development of fungal vaccines; features an in-depth analysis of the host-pathogen relationship.
Pathogenesis of Human Pulmonary Tuberculosis: Insights from the Rabbit Model
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This book provides in-depth insights into the pathogenesis of human tuberculosis and can serve as both a guide for future research and for the treatment of the disease. It covers the seminal work of Max B. Lurie in the rabbit model of tuberculosis, and the work of the author, who continued to research using the rabbit model after Lurie's death in 1966. updates Lurie's last work that was published in 1964 covering tuberculosis in the rabbit model offers an authoritative account of the current research using the rabbit model presents the pathogenesis of tuberculosis from the inhalation of the bacillus to a fully developed disease and its various manifestations details the key principles of tuberculosis pathogenesis illustrations the pathology of human disease using images from the renowned collection of A. R. Rich and W. G. MacCallum of the Johns Hopkins School of Medicine provides a comparison of tuberculosis in rabbits, mice, guinea pigs, and monkeys.
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Review : Radiation from Medical Procedures in the Pathogenesis of Cancer and Ischemic Heart Disease: Dose-Response Studies with Physicians per 100,000 Population
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Main Features : Radiation from Medical Procedures in the Pathogenesis of Cancer and Ischemic Heart Disease: Dose-Response Studies with Physicians per 100,000 Population
First the Bad News, Then the Good News. An honored scientist, who has a fine track-record of being correct, uncovers the first powerful evidence that xray procedures are a MAJOR cause, for men and women, of Cancer AND of Ischemic Heart Disease (also called Coronary Heart Disease, Coronary Artery Disease, and Myocardial Ischemia).
These two discoveries (not previously published elsewhere) point to a safe and painless way to achieve big reductions in mortality from both diseases --- because the undeniable benefits of xray procedures can be obtained, demonstrably, at much lower levels of xray dosage. Exposure to xrays, including fluoroscopy and CT scans, is a well-established cause of structural chromosomal aberrations and other mutations, even at very low doses and dose-rates.
Because the author's two discoveries are so startling, he shares at the outset (Chapter 1) the eight reasons which combine to make him confident that the findings are scientifically sound.
The content of this book is important to everyone who has either a professional or a personal interest in understanding and preventing Cancer and Ischemic Heart Disease. These two diseases account for 45% of deaths in the USA. The book presents strong evidence that medical radiation is one of their important causes.
Like detectives, many readers ENJOY evaluating evidence of causation. They seek data-and-logic, and are not intimidated by it. Such readers will find this to be a reader-friendly book. It uses no complex statistical operations. It shows each step between the raw data and the conclusions. And, because readers will "arrive" from many different fields, it defines even basic terms and concepts.
The nature of the evidence in this book will be comprehensible not only to biomedical and public health scientists, physicians, and undergraduate students worldwide, but also to non-medical scientists, engineers, lawyers, and health activists. The book begins with a short Introduction, an Abstract, and an Executive Summary.
Nearly all physicians --- whether they be radiologists, surgeons, gynecologists, cardiovascular specialists, general practitioners, or other --- either administer or "order" medical xrays. They need to know the findings and implications of this book for the health of their patients, regarding two of the most serious diseases in the United States. One implication: The undeniable benefits of xrays need to be, and demonstrably can be, obtained at much lower dose-levels than the levels commonly in use.
Patients today, who diligently inform themselves about the causes and prevention of various ailments, may wish to talk over the discoveries in this book with their own physicians.
Scientific inquiry is often organized around the exploration of hypotheses. Evidence is presented to test the validity of the hypotheses in logical ways. While an untested hypothesis is a speculation, hypotheses which PASS appropriate tests are the very substance of scientific knowledge.
This book presents a mountain of evidence which supports the two hypotheses stated on the book's cover. The first is that medical radiation is a highly important cause (probably the principal cause) of cancer mortality in the United States during the Twentieth Century. The second is that medical radiation, received even at very low and moderate doses, is an important cause of death from Ischemic Heart Disease; the probable mechanism is radiation-induction of mutations in the coronary arteries, resulting in dysfunctional clones (mini-tumors) of smooth muscle cells.
